Top malware November 2008 list from Dr.Web

Malware detected in e-mail traffic in November
1 Win32.HLLM.MyDoom.based 13741 (15.33%)
2 Win32.Virut 13036 (14.55%)
3 Win32.HLLM.Alaxala 5705 (6.37%)
4 Trojan.MulDrop.13408 4534 (5.06%)
5 Win32.HLLM.Beagle 4426 (4.94%)
6 Trojan.MulDrop.16727 4206 (4.69%)
7 Trojan.PWS.GoldSpy.2456 4145 (4.63%)
8 Win32.HLLW.Autoruner.2640 3032 (3.38%)
9 Trojan.MulDrop.18280 2580 (2.88%)
10 Trojan.PWS.Panda.31 2228 (2.49%)
11 Trojan.DownLoad.16843 2192 (2.45%)
12 Win32.HLLM.Netsky.35328 1888 (2.11%)
13 Win32.Virut.5 1497 (1.67%)
14 Win32.HLLM.MyDoom.33 1442 (1.61%)
15 Win32.HLLM.Netsky 1361 (1.52%)
16 Trojan.PWS.GoldSpy.2454 1328 (1.48%)
17 Trojan.MulDrop.19648 1310 (1.46%)
18 Win32.HLLW.MyDoom.43010 1306 (1.46%)
19 Win32.HLLM.Mailbot 1305 (1.46%)
20 Trojan.DownLoad.3735 1212 (1.35%)

Malware detected on user machines in November
1 Win32.HLLW.Gavir.ini 2039696 (21.98%)
2 Win32.HLLM.Lovgate.2 414507 (4.47%)
3 VBS.Autoruner.7 310657 (3.35%)
4 Win32.HLLM.Generic.440 288404 (3.11%)
5 VBS.Autoruner.8 277825 (2.99%)
6 Win32.Alman 275230 (2.97%)
7 DDoS.Kardraw 252853 (2.72%)
8 Win32.HLLP.Whboy 198018 (2.13%)
9 Trojan.Recycle 192769 (2.08%)
10 Win32.HLLP.Neshta 177445 (1.91%)
11 Win32.HLLP.Jeefo.36352 168291 (1.81%)
12 Win32.Virut.5 154206 (1.66%)
13 Win32.HLLW.Autoruner.274 147315 (1.59%)
14 Trojan.DownLoader.42350 132782 (1.43%)
15 Win32.HLLW.Autoruner.3631 120982 (1.30%)
16 VBS.Generic.548 110152 (1.19%)
17 Win32.HLLO.Black.2 97456 (1.05%)
18 Win32.HLLW.Autoruner.2805 89892 (0.97%)
19 Win32.HLLW.Cent 88296 (0.95%)
20 Trojan.MulDrop.18538 86521 (0.93%)

Source: http://www.drweb.com